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Minimum Information about a Tailoring Enzyme data repository (MITE)

Computational chemistryCatalysisCompounds and reactions

Natural products, also known as specialized or secondary metabolites, are small molecules produced by many organisms. These chemical compounds often show strong biological activities, making them interesting for medicine, agriculture, and other fields. Their biosynthesis is governed by a set of enzymes, which can be separated into gatekeeper/core enzymes, and tailoring enzymes. The latter modify the nascent natural products, giving them their final form, and often confer their biological activity. Tailoring enzymes show a wide range of substrate- and reaction-specificities. The Minimum Information about a Tailoring Enzyme (MITE) data standard was created to facilitate consistent and systematic deposition and retrieval of data on tailoring enzymes. Each MITE entry contains information on a single enzyme: its reaction(s), substrate specificities, known substrate-product pairs, and additional metadata. This record describes the data repository accompanying the data standard.

Website
Record in FAIRsharing
Subjects: Biochemistry, Bioinformatics, Computational Chemistry, Enzymology, Life Science, Medicinal Chemistry, Molecular Chemistry, Organic Chemistry

What is known per question

The questions of the decision tree, with what FAIRsharing says about this repository. ✓ supported, ✗ excluded, ? not known.

What kind of data do you want to archive?

? Spectra
? Crystal structures
✓ Computational chemistry
✓ Catalysis
✓ Compounds and reactions
? Bioassays and chemical biology
? Materials and polymers
? Images and microscopy
? Something else

Subjects: Biochemistry; Bioinformatics; Computational Chemistry; Enzymology; Life Science; Medicinal Chemistry; Molecular Chemistry; Organic Chemistry

Domains: Annotation; Biocuration; Enzyme Commission number; Reaction data; catalytic activity; chemical entity; curated information; enzymatic reaction; enzyme; metabolite; pathway